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Verapamil major verapamil may reduce total body clearance and extrarenal clearance of digitoxin by 27 and 29 , respectively; serum concentrations of orally administered digoxin can increase by 50 to 75 during the first week of combination therapy, possibly resulting in digitalis toxicity.
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Daunorubicin liposomal moderate some antineoplastic agents have been reported to decrease the absorption of digoxin tablets due to their adverse effects on the gi mucosa; the effect on digoxin liquid is not known.
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Digitalization may be accomplished by either of 2 general approaches that vary in dosage and frequency of administration, but reach the same endpoint in terms of total amount of digoxin accumulated in the body.
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